DIHYDROXYACETONE AND INSULIN HYPOGLYCEMIA

Insulin Therapy and Hypoglycemia - Present and Future

Preabsorptive insulin release and hypoglycemia in rats.

Peripheral blood glucose and immunologically reactive insulin levels were determined in freely moving normal rats which were submitted either to a free oral glucose load or to a gastric administration of the glucose load. Identical determinations were performed in ventromedial hypothalamic nucleus-(VMH) lesioned and vagotomized rats after the same oral intake. It was demonstrated that: 1) a fre...

Diabetes and hypoglycemia due to insulin antibodies.

A patient with "autoimmune diabetes" with reactive hypoglycemia due to anti-insulin antibodies is described. The pathophysiology of the impaired carbohydrate tolerance and reactive hypoglycemia is illustrated by measurements of C-peptide, and free and antibody-bound insulin. Detailed analysis of her antibodies did not provide any evidence in favor of exogenous insulin immunization. Nevertheless...

Kidney Injury, Insulin Therapy, and Hypoglycemia

The intent of this review is to evaluate the literature with respect to increased risk for hypoglycemia for critically ill patients with acute kidney injury or chronic kidney disease who are given insulin therapy. The unique pathophysiology of insulin and glucose metabolism during renal failure that predisposes patients for hypoglycemia is reviewed. Studies that contribute to the understanding ...

Paliperidone Induced Hypoglycemia by Increasing Insulin Secretion

We report the case of a 41-year-old woman with schizophrenia who developed persistent hypoglycemia following paliperidone administration. After discontinuing paliperidone, the hypoglycemia resolved, but symptoms of diabetes emerged. Therefore, it appears that the hypoglycemia induced by paliperidone may mask symptoms of diabetes. Paliperidone may induce hypoglycemia by increasing insulin secret...